Publications of Henry A. Spiller

Publications in the peer reviewed literature
  1. Spiller HA. Carbon Monoxide Exposure in the Home: Source and Epidemiology. Vet Hum Toxicol 1987 Oct:29;383-386.
  2. Spiller HA. Carbon Monoxide. TOXTALK 1988. Vol. 1, No. 4. (monograph)
  3. Spiller HA, Udicious T, Muir S. Angiotensin Converting Enzyme Inhibitor Ingestion In Children. J Toxicol - Clin Toxicol 1989:27;345-353
  4. Spiller HA, Picciotti M, Perez E. Accidental Terfenadine Ingestion In Children. Vet Hum Toxicol 1989 April:31;154-156
  5. Ramoska E, Spiller HA, Myers A. Calcium Channel Blocker Toxicity. Ann Emerg Med June 1990:19;649-653
  6. Spiller HA, Krenzelok E, Cooksan E. Carbamazepine Overdose: A Prospective Study of Serum Levels and Toxicity. J Toxicol - Clin Toxicol 1990:28;433-444
  7. Spiller HA, Morse S, Muir C. Fluoxetine Ingestion: A One Year Retrospective Study. Vet Hum Toxicol 1990 April:32;153-55
  8. Spiller HA, Myers A, Ziemba T, Reily M. Delayed Onset of Cardiac Arrhythmias From Sustained Release Verapamil: 2 Case Reports. Ann Emerg Med 1991:20;201-203
  9. Gorman RL, Khin-Maung-Gyi T, Klien-Schwartz W, Orderda GM, Benson B, Litovitz T, McCormick M, McElwee N, Spiller H, Krenzelok E. Initial Symptoms as Predictors of Esophageal Injury of Alkaline Corrosive Ingestion. Amer J Emerg Med 1992 May:10:189-194
  10. Spiller HA, Ramoska EA, Henretig FM, Jaffe M. Two Year Retrospective Study of Accidental Pediatric Albuterol Ingestion. Ped Emerg Care 1993 Dec:9;338-340
  11. Ramoska EA, Henretig F, Jaffe M, Spiller HA. Propranolol Treatment of Albuterol Poisoning in an Asthmatic. Ann Emerg Med 1993 Sept:22;1474-1476
  12. Ramoska EA, Spiller HA, Winter M, Borys D. One Year Evaluation of Calcium Channel Blocker Overdose: Toxicity and Treatment. Ann Emerg Med 1993 Feb:22;196-200
  13. Spiller HA, Krenzelok EP. Carbamazepine Overdose: Serum Concentration Less Predictive in Children. J Toxicol - Clin Toxicol 1993:31;459-460
  14. Spiller HA, Quadrani-Kushner DA, Cleveland P. A Five Year Evaluation of Acute Exposure to a Phenol Disinfectant (26%). J Toxicol - Clin Toxicol 1993:31;307-313
  15. Spiller HA, Ramoska EA. Isradipine Ingestion in a Two Year Old. Vet Human Toxicol 1993 June:35;233
  16. Spiller HA, Ramoska EA, Krenzelok EP, Sheen SR, BorysD, Villalobos D, Muir S, Jones-Easom, L. Bupropion in overdose: a Three Year Multicenter Retrospective Evaluation. Amer J Emerg Med 1994 Jan:12;43-45
  17. Spiller HA, Krenzelok EP, Grande GA. Safir E. A Prospective Evaluation of the Effect of the Use of Activated Charcoal before Oral N-acetylcysteine Therapy in Acetaminophen Overdose. Ann Emerg Med 1994 Feb:23;519-523
  18. Wiley JF, Spiller HA, Krenzelok EP, Borys D. Accidental Albuterol Ingestion in Children. Ped Emerg Care 1994 Aug:10:193-196
  19. Sheen SR, Spiller HA, Grossman D. Symptomatic Brodifacoun Ingestion Requiring High Dose Phytonadione Therapy. Vet Human Toxicol 1994:36;216-217
  20. Spiller, HA, Penn E, Richards W. Poison Prevention and Education Program: Curriculum Guide for Teachers. Kentucky Regional Poison Center publication for Preschool and Primary School Teachers. 1994
  21. Spiller HA, Winter ML, Mann KV, Borys DJ, Muir S, Krenzelok EP. Five Year Multicenter Retrospective Review of Cyclobenzaprine Toxicity. J Emerg Med 1995:13; 781-785
  22. Spiller HA, Krenzelok EP. Acetaminophen Overdose. Ann Emerg Med 1995 Jan:24;118
  23. Spiller HA, Willias DB, Gorman SE, Sanftleban J. Retrospective Study of Mistletoe Ingestions. J Toxicol - Clin Toxicol 1996:34 (4);405-408
  24. Spiller HA, Bosse GM. Management of Antiepileptic Drug Overdose. CNS Drugs. 1996 Aug:6 (2);113-129
  25. Spiller HA, Shirley BA. Healthcare facility utilization for poisoning exposures in urban and rural populations. Vet Human Toxcicol 1996:38;459
  26. Quadrani DA, Spiller HA, Widder P. Five Year Retrospective Evaluation of Sulfonylurea Ingestion in Children. J Toxicol - Clin Toxicol 1996:34;267-270
  27. Spiller HA. The Kentucky Regional Poison Center. Kentucky Phamacist 1996 Jan;12-13
  28. Spiller HA, Villalobos D, Krenzelok EP, Anderson BD, Gorman SE, Rose SR, Fenn J, Anderson DL , Muir SJ,. Rodgers GC. Prospective Multicenter Study of Sulfonylurea Ingestion in Children. J Pediatr 1997 July;131:143-148
  29. Quadrani DA, Spiller HA. Sulfonylurea Ingestion in Children. J Toxicol - Clin Toxicol 1997:35 (1); 117-118
  30. Spiller HA, Bosse GM. Management of Antiepileptic Drug Overdose. Medical Progress 1997 Jan:24;21-26
  31. Spiller HA, Krenzelok EP. Epidemiology of Inhalant Abuse Reported to Two Regional Poison Centers. J Toxicol - Clin Toxicol 1997;35 (2): 167-173
  32. Spiller HA, Gorman SE, Villalobos D, Benson BE, Ruskosky DR, Stancavage MM, Anderson DL. Prospective Multi-center Evaluation of Tramadol Exposure. J Toxicol - Clin Toxicol 1997;35(4):361-364
  33. Spiller HA, Schroeder S, Ching DSY. Hemiparesis and altered mental status in a child after glyburide ingestion. J Emerg Med 1998;16 (3): 433-435
  34. Brito MA Reyes RM, Arguello JR, Spiller HA. Principal causes of poisoning in Quito, Ecuador: a retrospective epidemiology study. Vet Human Toxicol 1998;40:40-42
  35. Spiller HA. Management of Antidiabetic Medications in Overdose. Drug Safety 1998 Nov;19(5): 411-424
  36. Spiller HA. New antidote for ethylene glycol toxicity. Reviews and Updates in Toxicology. 1998 Spring (monograph)
  37. Spiller HA, Krenzelok EP, Anderson BD. Sulfonylurea ingestion in children: is an 8-hour observation period sufficient? J Pediatr 1998 Oct; 133 (4): 584-585
  38. Ross MP, Spiller HA. Fatal ingestion of sodium hypochlorite bleach with Associated hypernatremia and hyperchloremic metabolic acidosis. Vet Human Toxicol 1999:41;82-86
  39. Spiller HA. Management of sulfonylurea ingestion. Ped Emerg Care 1999;15: 227-230
  40. Quadrani DA, Spiller HA, Stienhorn D. A fatal case of gun blue ingestion in a toddler. Vet Human Toxicol. 2000;42:96-98
  41. Spiller HA, Weber J, Winter M, Klein-Schwartz W, Hofman M, Gorman S, Stork C, Krenzelok EP Multicenter case series of pediatric metformin ingestion. Ann Pharmacotherp 2000;34(12):1385-1389
  42. Spiller HA, Revolinski DH, Winter ML, Weber JA, Gorman SE. Multi-center retrospective evaluation of oral benzocaine exposure in children. Vet Human Toxicol. 2000;42: 228-231
  43. Spiller HA, Krenzelok EP, Klein-Schwartz W, Winter ML, Weber JB, Sollee DR, Bangh SA. Multicenter case series of valproic acid ingestion: serum concentrations and toxicity. J Toxicol Clin Toxicol 2000;38:755-760
  44. Spiller HA. Green tobacco Sickness: a review. Internet continuing education module. Found at http://www.krpc.com
  45. Spiller HA, Carlyle R. Timely antemortem and postmortem concentrations in a fatal carbamazepine overdose. J Foren Sci 2001;46:1510-1512
  46. Spiller HA. MDMA (3,4 methylenedioxymethamphetamine) “Ecstasy”: a review. Internet continuing education module Found at http://www.krpc.com
  47. Spiller HA, Rodgers GC. Prospective Evaluation of Administration of Activated Charcoal in the Home. Pediatrics 2001;108(6). Available at http:\\www.pediatrics.org\CGI\content\full\108\6\e100
  48. Spiller HA. Persistently elevated acetaminophen levels for two days after initial four-hour non-toxic level. Vet Human Toxicol 2001;43:218-219
  49. Spiller HA, Krenzelok EP. Are there any unique valproic acid ingestions? J Toxicol Clin Toxicol 2001;39:421-422
  50. Spiller HA. Management of carbamazepine in overdose. Ped Emerg Care 2001;17:452-456
  51. Spiller HA, Carlyle RD. Status epilepticus after massive carbamazepine overdose. J Toxicol Clin Toxicol 2002;40;81-90
  52. Spiller HA, Hale J. de Boer J. Ancient inhalers: The Oracle of Delphi. Mithridata 2002 (Jan);XII (1): 3-8
  53. Spiller HA, Wahlen HS, Stephens TL, Krenzelok EP, Benson BE, Peterson J, Dellinger JA. Multi-center retrospective evaluation of carbonyl iron ingestion. Vet Hum Toxicol 2002;44:28-29
  54. Spiller HA, Hale JR, de Boer JZ. The oracle at Delphi: a multi-disciplinary defense of the gaseous vent theory. J Toxicol Clin Toxicol 2002;40:189-196
  55. Spiller HA, Villalobos D, Benson B, Krenzelok EP, Anderson D. Retrospective Evaluation Of Cetirizine (Zyrtec ®) Ingestion. J Toxicol Clin Toxicol 2002 44:297-298
  56. Mattingly JE, Sullivan JE, Spiller HA, Bosse GM. Intermediate Syndrome After Exposure To Chlorpyrifos In A 16-Month-Old Female. J Emerg Med 2003:25:379-381
  57. Spiller HA, Schultz OE. Envenomation: a novel drug seeking method. Vet Human Toxicol 2002:44;297-298
  58. Spiller HA, Dunaway MD Cutino L. Massive Gabapentin and Presumptive Quetiapine Overdose. Vet Human Toxicol 2002:44:243-244
  59. Spiller, HA. Conflicting Views in Poison Treatment. Pediatrics 2002;110:199-200
  60. Spiller HA, Baker D, Krenelok EP, Cutino L. Use of dosage as a triage guideline for unintentional cyclic antidepressant (UCA) ingestions in children. Amer J Emerg Med 2003;21:422-424
  61. Spiller, HA. Home administration of charcoal. J Emerg Med 2003:25 (1): 106-107
  62. Spiller HA, Cutino L. Fatal Cyclobenzaprine Overdose With Post Mortem Values J Foren Sci 2003;48:883-884
  63. Spiller HA. Post-Mortem Oxycodone And Hydrocodone Concentrations. J Foren Sci 2003;48:429-431
  64. Spiller HA, Winter ML, Weber JA, Krenzelok EP, Anderson DA, Ryan M. Skin breakdown and blisters from senna containing laxatives in young children. Ann Pharmacotherp 2003;37:636-639
  65. Spiller HA, Bosse GM. Prospective study of morbidity associated with snakebite envenomation. J Toxicol Clin Toxicol 2003;41:125-130
  66. Hale JR, de Boer JZ, Chandler J, Spiller HA. Questioning the Delphic oracle. Scientific Amer 2003: 289:66-73
  67. Spiller HA, Gallenstein GL, Murphy MJ. Dermal absorption of a liquid diphacinone rodenticide causing coagulaopathy. Vet hman Toxicol 2003;45:313-314
  68. Spiller HA. Epidemiology of volatile substance abuse (VSA) cases reported to US poison centers. Amer J Drug Alcoh Abuse 2004;30(1):155-165
  69. Spiller HA, Quadrani DA. Five year retrospective review of toxic effects from metformin exposure. Ann Pharmacother 2004;38(5):776-80
  70. Spiller HA, Bosse GM, Anderson LA. Retrospective Review of Tizanidine (Zanaflex) Overdose J Toxicol Clin Toxicol 2004;42:593-596
  71. Hunsaker DM, Spiller HA, Williams D. Acute selenium poisoning: Suicide by ingestion. J Foren Sci 2005:50:942-946
  72. Spiller HA, Mowry JB. Evaluation of the effect of a public educator on calls and poisonings reported to a regional poison center. Vet Human Toxicol 2004;46:206-208
  73. Spiller HA, Winter ML, Klein-Schwartz W, Bangh SA. Efficacy of activated charcoal administered more than four hours after acetaminophen overdose. J Emerg Med. 2006:30:1-5
  74. Spiller HA, Klein-Schwartz W, Colvin JM, Villalobos D, Johnson PB, Anderson DL. Toxic clonidine ingestion in children. J Pediatr 2005;146:263-266
  75. McKnight RH, Spiller HA. Green tobacco sickness in children and adolescents. Pub Health Reports 2005;120:602-605
  76. Hunsaker DM, Hunsaker JC, Clayton T, Spiller HA. Lethal envenomation: Medicolegal aspects of snakebites and religious snake handlers in Kentucky. J KY Med Assoc 2005;103:543-556
  77. Spiller HA, Winter ML, Ryan M, Krenzelok EP, Anderson DL, Thompson M, Kumar S. Retrospective evaluation of tiagabine overdose. J Toxicol Clin Toxicol 2005;43:855-859
  78. Compton R, Spiller HA, Bosse GM. Fatal fluoxetine ingestion with postmortem values. J Toxicol Clin Toxicol 2005;43:277-279
  79. Spiller HA, Lintner CP, Winter ML. Atomoxetine ingestions in children: a report from poison centers. Ann Pharmacother 2005;39:1045-1048
  80. Simms L, Walsh J, Spiller HA, Kaelin C, Thoroughman D. Mercury exposure, Kentucky - 2004. MMWR 2005;54:796-799
  81. Spiller HA, Baker DA, Smith GS, LoVecchio F. Pramoxine ingestion in humans. Ann Pharmacother 2006;40:996-997
  82. Spiller HA, Sawyer TS. Toxicology of oral antidiabetic medications. Amer J Health Sys Pharm 2006;63:929-937
  83. Spiller HA, Klein-Schwartz W. Clonidine ingestion in children is not uneventful. J Pediatr 2006;148:850-851
  84. Spiller HA, Sawyer TS. Antidepressant withdrawal syndrome and DUI evaluation. Foren Examiner 2007;16(3):50-54
  85. Spiller HA, Sawyer TS. Impact of activated charcoal (AC) after acute acetaminophen overdoses treated with N-acetylcysteine (NAC). J Emerg Med 2007;33:141-144 http://dx.doi.org/10.1016/j.jemermed.2007.02.016
  86. Smolinske S, White S, Daubert GP, Didrichsons R, Eisenga B, Mowry J, Mrvos R, Krenzelok EP, Casavant M, Baker DA, Spiller HA. Respiratory Illness associated with boot sealant products – five states, 2005-2006. MMWR 2006;55;488-490
  87. Klein-Schwartz W, Lofton AL, Benson BE, Spiller HA, Crouch BI. Prospective multi-poison center study of ziprasidone overdose. Clin Toxicol 2007;45:782-786
  88. Spiller HA, Pfiefer E. Two fatal cases of selenium toxicity. Foren Sci Int 2007;171:67-72 http://dx.doi.org/10.1016/j.forsciint.2006.06.077
  89. Spiller HA, Klein-Schwartz W. Clonidine toxicity. J Pediatr 2006;149:282-283
  90. Spiller HA, Rogers J, Sawyer TS. Drug Facilitated Sexual Assault using an over-the-counter ocular solution containing tetrahydrozoline (Visine). Legal Med 2007;9:192-195 http://dx.doi.org/10.1016/j.legalmed.2007.01.005
  91. Spiller HA, Willias D. Daphne Caucasica Ingestion in a Child. Clin Toxicol 2008;46:912
  92. Gascon DJ, Spiller HA. Relationship of Unemployment Rate on Rate of Opiate Exposure in Kentucky. J Psychoactive Drug 2009;41:99-102
  93. Spiller HA, Griffith JR. Prolonged cardiovascular effects after unintentional ingestion of tetrahydrozoline. Clin Toxicol 2008;46:171-172
  94. Bunn TL, Slvova S, Spiller HA, Colvin J. The Effect of Poison Control Center Consultation, Pre-existing Medical Conditions and Other Factors on Poisoning Inpatient Hospitalizations. J Toxicol Environ Health (part A) 2008;71:283-288
  95. Spiller HA, Aleguas A. Agricultural Chemical Exposure in Small Farmers in Guyana. Toxicol Environ Chem 2008;90:361-365  http://dx.doi.org/10.1080/02772240701526679
  96. Spiller HA, Bottei E, Kalin L. Fatal bupropion overdose with post mortem blood concentrations. Foren Sci Med Pathol 2008;4:47-50   DOI 10.1007/s12024-007-0030-5
  97. McCain KR, Sawyer TS, Spiller HA. Evaluation of Adult Centrally Acting Cholinesterase Inhibitor Exposures. Ann Pharmacother 2007:41:1632-7 www.doi.org/10.1345/aph.1K139
  98. Spiller HA, Rodgers GC, Willias DB, Bosse GM, Sullivan J. Methemoglobinemia due to Malachite Green ingestion in a child. Clin Toxicol 2008;46:320-321 http://dx.doi.org/10.1080/15563650701387200
  99. Spiller HA, Schaeffer SE. Multiple seizures after bupropion overdose in a small child. Pediatr Emerg Care 2008;24:474-475
  100. Spiller HA, de Boer J, Hale JR, Chanton J. Gaseous Emissions at the site of the Delphic Oracle: Assessing the Ancient Evidence. Clin Toxicol 2008;46:487-488
  101. Spiller HA. Lacitc acidosis. Diabetes Self Management 2007 Mar/Apl:72 (letter)
  102. Collins A, Bosse GM, Spiller HA. A Fatal Case of Venlafaxine Overdose. J Med Toxicol 2008;4:18-20
  103. Spiller HA, Lorenz DJ. Trends in Volatile Substance Abuse (VSA). J Add Dis 2009;28;164-170
  104. Spiller HA, Bosse GM, Beuhler M, Gray T, Baker SD. Unintentional Ingestion of bupropion in children. J Emerg Med 2009 (accepted - in press)
  105. Cicero TJ, Spiller HA. Chronic pain, addiction and the law: a focus on Kentucky. Clin Courier 2007;25 (18):1-8 (ISSN 0264-6684)
  106. Spiller HA. Hypotension after ingestion of Aliskiren. Clin Toxicol 2008;46;916-917
  107. Spiller HA, Griffith JRK, Bratcher R. Pregabalin overdose with benign outcome. Clin Toxicol 2008;46:917
  108. Starr P, Klein-Schwartz W, Spiller HA, Herzog P, Ekleberry SE, Kunkel S. Incidence and Onset of Delayed Seizures Following Overdoses of Extended Release (XL) Bupropion Amer J Emerg Med 2009;27:911-915
  109. Spiller HA, Borys D, Griffith JRK, Klein-Schwartz W, Aleguas A, Solle D, Anderson DA, Sawyer TS. Toxicity of modafinil ingestion Clin Toxicol 2009;47:153-156
  110. Spiller HA, Griffith JRK, Anderson DL, Weber JA, Aleguas A.Poison centers detect an unexpectedly frequent number of adverse drug reactions to lisdexamfetamine. Ann Pharmacotherapy 2008;42:1142-1143
  111. Spiller HA, Lorenz DJ, Bailey JE, Dart RC. Epidemiological trends in abuse and misuse of prescription opioids. J Add Dis 2009;28:130-136
  112. Spiller HA, Griffith JRK. The value and evolving role of the US Poison Center system. Pub Health Reports 2009;124(3):359-363
  113. Griffith JRK, Spiller HA, Weber JA, Foster H, Casavant M, Baker SD. Retrospective review of duloxetine toxicity. Human Exp Toxicol  (in review)
  114. Beuhler MC, Sasser H, Spiller HA. The outcome of unintentional pediatric bupropion ingestions: A NPDS database review. J Med Toxical (accepted - in press)
  115. Berger JR, Houff S, Tucker T, Allen T, Levin B, Schmitt F, Mattingly M, Given C, Spiller HA. The Neurological and Psychiatric Complications of Carbon Monoxide Soaking: Report of 31 Patients with Industrial Exposure.  Amer J Indus Med 2009 (in review)
  116. Padmanabhan P, Bosse GM, Spiller HA. Hypercalcemia and gastric necrosis from hot pack ingestion. J Med Toxicol (accepted - in press)
  117. Daubert GP, Spiller HA, Crouch BI, Seifert S, Simone K, Smolinske SC. Pulmonary toxicity following exposure to waterproofing grout sealer. J Med Toxicol 2009;5:125-129
  118. Spiller HA, Bosse GM, Ryan ML. Use of antivenom for snakebites reported to US poison centers. Amer J Emerg Med 2009 (accpeted - in press)
  119. Spiller HA, Griffith JRK. Increasing burden of Pill identification requests to US poison Centers. Clin Toxicol 2009;47:253-255
  120. Bunn TL, Yu L, Spiller HA, Singleton M. Surveillance of methadone-related poisonings in Kentucky using multiple data sources. Pharmacoepidemiol Drug Safety 2009 (in review)
  121. Engel JS, Spiller HA. Acute ethanol poisoning in a 4 year old as a result of ethanol-based hand sanitizer ingestion. Pediatr Emerg Care 2009 (Accepted - in press)
  122. Winter ML, Spiller HA, Griffith JRK. Benzonatate ingestion reported to the National Poison Center Database System (NPDS). Ann Pharmacother 2009 (in review)
  123. Spiller HA, Bailey JE, Dart RC, Spiller SS. Investigation of Temporal changes of abuse and misuse of prescription opioids. J Add Dis 2009 (Accepted – in press)
  124. Spiller HA, Singleton MD. Evaluation of the Effect of a Poison Center on Emergency Department Utilization for Poisonings. Clin Toxicol (in review)

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Book Chapters

Television Appearences

The subject of the following documentaries was the work by our 4 member team to use modern science to explain and defend the gaseous vent theory of the Oracle of Delphi, in the temple of Apollo. The Oracle was a prominent and important ancient religious site in Bronze Age Greece. I served as the toxicologist of the team, which included a Geologist, an Archeologist and a Chemist and a Toxicologist.

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Continuing Education and Symposiums attended

Awards

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